Nonclinical Safety and Toxicokinetics of MnTnBuOE-2-PyP5+ (BMX-001)
نویسندگان
چکیده
منابع مشابه
A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function
The signaling of reactive oxygen species (ROS) is essential for the maintenance of normal cellular function. However, whether and how ROS regulate stem cells are unclear. Here, we demonstrate that, in transgenic mice expressing the human manganese superoxide dismutase (MnSOD) gene, a scavenger of ROS in mitochondria, the number and function of mouse hematopoietic stem/progenitor cells (HSPC) un...
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Cranial irradiation is a standard therapy for primary and metastatic brain tumors. A major drawback of radiotherapy (RT), however, is long-term cognitive loss that affects quality of life. Radiation-induced oxidative stress in normal brain tissue is thought to contribute to cognitive decline. We evaluated the effectiveness of a novel mimic of superoxide dismutase enzyme (SOD), MnTnBuOE-2-PyP(5+...
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Atacicept, a soluble recombinant fusion protein of the human immunoglobulin (Ig) G(1) Fc and the extracellular domain of the human transmembrane activator and calcium modulator and cyclophylin ligand interactor receptor, acts as an antagonist of both B lymphocyte stimulator and a proliferating-inducing ligand. Here we determined the nonclinical safety, pharmacokinetics and pharmacodynamics of a...
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Although radiation therapy can be effective against cancer, potential damage to normal tissues limits the amount that can be safely administered. In central nervous system (CNS), radiation damage to normal tissues is presented, in part, as suppressed hippocampal neurogenesis and impaired cognitive functions. Mn porphyrin (MnP)-based redox active drugs have demonstrated differential effects on c...
متن کاملBook Review: Toxicologic Pathology, Nonclinical Safety Assessment
Book Review: Toxicologic Pathology, Nonclinical Safety Assessment, Edited by Sahota PS, Popp JA, Hardisty JF, and Gopinath C, CRC Press, 1,015 pages, 158 color illustrations, 43 tables, 2013. Hardback version (ISBN 9781-4398-7210-9; $259.95) and ebook version (ISBN 978-14398-7212-3; $181.97). Katsuhiko Yoshizawa, DVM, MS, PhD, DJSTP, DJCVP, DJST, FIATP Kansai Medical University Department of Pa...
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ژورنال
عنوان ژورنال: International Journal of Toxicology
سال: 2016
ISSN: 1091-5818,1092-874X
DOI: 10.1177/1091581816642766